Dosehost
Clinical evidence

Backed by peer-reviewed research.

SmartOx builds on a body of peer-reviewed trials and meta-analyses in COPD oxygen therapy. The figures here come from published studies of the clinical approach, in exercise and hospital settings. They are not SmartOx trial results, and full references are available on request.

Patient outcomes

Patients walk further and breathe easier.

98%
Longer walking time
Randomized crossover trial · Journal of Clinical Medicine, 2021
+237s
Longer exercise endurance
Systematic review and meta-analysis · BMC Pulmonary Medicine, 2025
+29%
More time in the target oxygen range during exercise
Systematic review and meta-analysis · BMC Pulmonary Medicine, 2025
50%
Lower breathlessness scores
Randomized crossover trial · Journal of Clinical Medicine, 2021

Patient outcomes from peer-reviewed clinical research. Full citations available on request.

Health-system outcomes

Fewer days in hospital, lower cost of care.

Hospital studies of the same clinical approach show shorter stays, more time in the target oxygen range, and lower per-patient costs.

2.2 days
Shorter hospital stays
Systematic review and meta-analysis · Respiration, 2019
81% vs 51%
Time in the target oxygen range, hospital pilot trial
Pilot randomized trial · International Journal of COPD, 2016
20.7%
Lower per-patient hospital costs at 180 days
Cost-effectiveness analysis · BMJ Open, 2018
The readmission problem

The cost of the gap shows up in the hospital.

COPD is one of the most frequent reasons Americans return to the hospital within a month of leaving it. Readmissions are expensive, often preventable, and closely tied to how patients are doing at home.

1 in 5
COPD hospital stays lead to a readmission within 30 days
Nationwide Readmissions Database (AHRQ HCUP), 2013–2014
100,000+
COPD readmissions in the US every year
Nationwide Readmissions Database (AHRQ HCUP), 2013–2014
$6B+
spent annually on COPD hospitalizations
AHRQ HCUP, 2008
Oxygen saturation (SpO₂) at home, illustrative
Safe SpO₂ thresholdNext clinic visit
01

Drops go unseen at home.

Patients on home oxygen can fall below safe oxygen levels during ordinary daily activity. A resting check in clinic will not catch it.

02

The clinic finds out late.

Clinicians usually learn how a patient is doing at the next scheduled visit, or once something has already gone wrong.

03

Exacerbations are ~50% more likely.

Patients who desaturate during a walking test were about 50% more likely to have had an exacerbation in the past year, the kind that sends a patient back to the hospital.

Cohort of 1,789 patients · International Journal of COPD, 2025

What clinicians told us

3 in 4 specialists are not confident their patients use oxygen as prescribed.

From a 2026 survey of 30 US pulmonary specialists and practice staff, fielded by MaRS.

More findings are in the evidence brief, sent to qualified organizations on request.

References

Full citations, including DOIs, are available on request. Clinical figures are drawn from randomized trials and meta-analyses published between 2016 and 2025; readmission figures are from the US Agency for Healthcare Research and Quality.

Want the evidence brief?

A short summary of the clinical research, the readmission burden, and the clinician survey, sent to qualified organizations on request.